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Meet Trulicity
1 Meet Trulicity 2 Resources for the Pharmacy 3 Getting Started 4 About Side Effects 5 Looking Ahead

In adult patients with type 2 diabetes

Most common side effects

  • Nausea

  • Diarrhea

  • Vomiting

  • Abdominal pain

  • Decreased appetite

  • Indigestion

  • Fatigue

Nausea happens most often when first starting Trulicity (dulaglutide)

How many people experienced nausea?

In studies, 8%-29% percent of people using Trulicity experienced nausea.

How long should nausea last?

In a majority of patients who experienced nausea, it typically occurred during the first 2-3 days after they took their first dose. Nausea generally subsided after the first 2 weeks, but some experienced it beyond their second week of treatment. Less than 2% needed to stop taking Trulicity because of nausea.*

*The most common gastrointestinal side effects with Trulicity may include nausea, diarrhea, vomiting, abdominal pain, and decreased appetite. In studies, GI side effects were more common in people taking Trulicity than people taking placebo, and people taking Trulicity were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure). Trulicity may cause severe stomach problems.

When you increase your dose of Trulicity, you might experience nausea. With the higher dose options, about 16% of adults experienced nausea and about 1% of adults needed to stop taking Trulicity because of it.*

*The most common adverse reactions experienced with Trulicity are nausea, diarrhea, vomiting, abdominal pain, decreased appetite, indigestion and fatigue. The rates of nausea, vomiting and diarrhea, while numerically higher in each of the higher dulaglutide groups compared with the 1.5 mg group were similar between the dulaglutide 3.0 mg and 4.5 mg groups in a clinical trial. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure). Trulicity may cause severe stomach problems.

Select Important Safety Information

Ask your healthcare provider how to recognize possible serious side effects and what to do:

Acute kidney injury. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration). This may cause kidney problems to get worse.

A few tips for managing nausea

If you experience nausea, talk to your doctor. In the meantime, some people find the following tips may help:

An X icon overlaid on a cheeseburger and fries

Avoid fried or other fatty foods

Try eating bland foods like toast, crackers, or rice

Four plates with silverware on top

Try splitting your 3 daily meals into 4 or more smaller ones

Hear from other users
Safety Summary With Warnings

Warnings: Trulicity may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

  • Do not use Trulicity if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).

  • Do not use Trulicity if you have Multiple
Indications

Safety Summary With Warnings

Warnings: Trulicity may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

  • Do not use Trulicity if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).

  • Do not use Trulicity if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

  • Do not use Trulicity if you are allergic to dulaglutide or other ingredients in Trulicity.

Ask your healthcare provider how to recognize possible serious side effects and what to do :

Inflamed pancreas (pancreatitis). Stop using Trulicity and call your healthcare provider right away if you have severe pain in your stomach area (abdomen), with or without vomiting, that will not go away. You may feel the pain from your abdomen to your back.
Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use TRULICITY with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin.
Signs and symptoms of low blood sugar may include dizziness or light-headedness, confusion or drowsiness, headache, blurred vision, slurred speech, fast heartbeat, sweating, hunger, shakiness, feeling jittery, weakness, anxiety, irritability, or mood changes.
Serious allergic reactions. Stop using Trulicity and get medical help right away if you have any symptoms of a serious allergic reaction which may include swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting, or feeling dizzy, or very rapid heartbeat.
Acute kidney injury. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration). This may cause kidney problems to get worse.
Severe stomach problems. Trulicity may cause stomach problems, which could be severe.
Changes in vision. Tell your healthcare provider if you have changes in your eyesight (vision) during treatment with Trulicity.
Gallbladder problems. Gallbladder problems have happened in some people who take Trulicity. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), clay-colored stools.

Common side effects

The most common side effects of Trulicity include nausea, diarrhea, vomiting, abdominal pain and decreased appetite, indigestion, and fatigue.

These are not all the possible side effects of Trulicity.

Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

  • Your healthcare provider should show you how to use Trulicity before you use it for the first time.

  • Before you use Trulicity, talk to your healthcare provider about low blood sugar and how to manage it.

Review these questions with your healthcare provider:

  • Do you have other medical conditions, including problems with your pancreas, kidneys, liver, or stomach, or have a history of diabetic retinopathy (vision problems related to diabetes)?

  • Do you take other diabetes medicines, such as insulin or sulfonylureas?

  • Are you pregnant or plan to become pregnant or breastfeeding or plan to breastfeed?

  • Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?

How to take

  • Read the Instructions for Use that come with Trulicity.

  • Use Trulicity exactly as your healthcare provider says.

  • Do not share your Trulicity pen, syringe, or needles with another person.

  • Do not give Trulicity to other people.

  • If you take too much Trulicity, call your healthcare provider or seek medical advice promptly.

Learn more

Trulicity is a prescription medicine. For more information, call 1-844-TRU-INFO (1-844-878-4636) or go to www.TRULICITY.com.

This summary provides basic information about Trulicity but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Trulicity and how to take it. Your healthcare provider is the best person to help you decide if Trulicity is right for you.

DG CON HL BS 17NOV2022

Trulicity® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Indications

Trulicity® (Trῡ-li-si-tee) is for adults and children 10 years of age and older with type 2 diabetes used along with diet and exercise to improve blood sugar (glucose). Trulicity is also used in adults with type 2 diabetes to reduce the risk of major cardiovascular events (problems having to do with the heart and blood vessels) such as death, heart attack, or stroke in people who have heart disease or multiple cardiovascular risk factors.

  • It is not known if TRULICITY can be used in people who have had inflammation of the pancreas (pancreatitis). TRULICITY is not for use in people with type 1 diabetes and is not recommended for use in people with severe stomach or intestinal problems. It is not known if TRULICITY is safe and effective in children under 10 years of age.

  • Trulicity is given through an injection (needle). You take it once a week by injecting it under the skin of your stomach, thigh, or upper arm.